New spray offers hope for people with common sleep condition

ChicagoGranny · Post by **ChicagoGranny** » Mon Apr 15, 2024 12:48 pm

Small study:

New spray offers hope for people with common sleep condition. ...
"Using a randomised, blind trial, 10 people with sleep apnoea were given either the potassium blocker nasal spray, a placebo nasal spray or the potassium nasal spray in combination with restricted 'nasal only' breathing. ...

When used in a nasal spray, the blockers have the potential to increase the activity of the muscles that keep the upper airway open and reduce the likelihood of the throat collapsing during sleep," lead author Dr Amal Osman, said.

Seven out of the 10 people responded to the potassium channel blocker nasal spray, with is causing a reduction in the frequency of upper airway collapsing episodes during sleep.
They also had lower blood pressure the next morning.

He said the insight offers a pathway to developing new drugs for the condition.

https://journals.physiology.org/doi/abs ... 00541.2023

CPAP is the proven Gold Standard for treating sleep apnea.

vandownbytheriver · Post by **vandownbytheriver** » Mon Apr 15, 2024 2:12 pm

Interesting abstract... thanks for posting it CG.

Potassium channel blockers are used for hypertension... I'm on Spironolactone. My bloodwork has shown high K... other medicines I'm on tend to push it the other way. Not surprising at all that the BP went down in the morning... I'm not ready to associate this with 'reduced severity' of OA's when the AHI did not perceptibly change. Note that the improvement was only noted in those not restricted to nasal breathing... what's up with that? It opens the throat, but not the upper airway?

There was no systematic change in apnea-hypopnea index (AHI3) from placebo versus BAY2586116 with either unrestricted or nasal-only breathing versus placebo (47 ± 26 vs. 43 ± 27 vs. 53 ± 33 events/h, P = 0.15). However, BAY2586116 (unrestricted breathing) reduced OSA severity in physiological responders compared with placebo (e.g., AHI3 = 28 ± 11 vs. 36 ± 12 events/h, P = 0.03 and ODI3 = 18 ± 10 vs. 28 ± 12 events/h, P = 0.02).

I guess it's appearing to me to be a liquid Inspire, albeit weaker. I'm getting better results (lowered AHI) from using a MAD before bed.

Pugsy · Post by **Pugsy** » Mon Apr 15, 2024 2:42 pm

Where do I sign up???

I want a nasal spray that will fix my OSA and BP at the same time.

While I am wanting things how about something to help me lose the last 20 pounds that I want gone???

Hey.....a girl can wish can't she?

ChicagoGranny · Post by **ChicagoGranny** » Mon Apr 15, 2024 3:36 pm

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 2:12 pm
Note that the improvement was only noted in those not restricted to nasal breathing... what's up with that?

Check it. It's the other way around. The study was restricted to those who do not breathe through the mouth. It could be poorly absorbed in those who mouth-breathe.

vandownbytheriver · Post by **vandownbytheriver** » Mon Apr 15, 2024 4:24 pm

ChicagoGranny wrote: ↑
Mon Apr 15, 2024 3:36 pm

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 2:12 pm
Note that the improvement was only noted in those not restricted to nasal breathing... what's up with that?
Check it. It's the other way around. The study was restricted to those who do not breathe through the mouth. It could be poorly absorbed in those who mouth-breathe.

I posted the quote... seems pretty clear to me. Two groups, one mouth-taped, one not. Benefit noted in the non-mouth-taped bunch. Am I on crack?

ChicagoGranny · Post by **ChicagoGranny** » Mon Apr 15, 2024 4:51 pm

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 4:24 pm
Two groups, one mouth-taped, one not.

There's only one group that was studied three times.

How do you interpret the following sentence?

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 2:12 pm
There was no systematic change in apnea-hypopnea index (AHI3) from placebo versus BAY2586116 with either unrestricted or nasal-only breathing versus placebo (47 ± 26 vs. 43 ± 27 vs. 53 ± 33 events/h, P = 0.15).

Sounds like all three "groups" had severe OSA.

vandownbytheriver · Post by **vandownbytheriver** » Mon Apr 15, 2024 6:24 pm

ChicagoGranny wrote: ↑
Mon Apr 15, 2024 4:51 pm

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 4:24 pm
Two groups, one mouth-taped, one not.
There's only one group that was studied three times.

How do you interpret the following sentence?

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 2:12 pm
There was no systematic change in apnea-hypopnea index (AHI3) from placebo versus BAY2586116 with either unrestricted or nasal-only breathing versus placebo (47 ± 26 vs. 43 ± 27 vs. 53 ± 33 events/h, P = 0.15).
Sounds like all three "groups" had severe OSA.

Yep... no change in AHI. So you're saying they ran it several times and swapped around the taped and untaped folks?

There was no systematic change in apnea-hypopnea index (AHI3) from placebo versus BAY2586116 with either unrestricted or nasal-only breathing versus placebo

Unrestricted means able to mouth-breathe, right? Nasal-only... taped mouth/chinstrap right? Reduced severity of events noted only in unrestricted cohort, right?

ChicagoGranny · Post by **ChicagoGranny** » Tue Apr 16, 2024 10:53 am

vandownbytheriver wrote: ↑
Mon Apr 15, 2024 6:24 pm
So you're saying they ran it several times and swapped around the taped and untaped folks?

1. They ran all ten subjects through with a placebo.

2. Later, they ran all ten subjects with the spray and untaped.

3. Later, they ran all ten subjects with the spray and taped.

My conclusion: It was a very small study with questionable results. The study might be useful to justify additional studies:

"What we have discovered is that the nasal spray application of the potassium channel blocker that we tested is safe, well tolerated, " Dr Osman (the study author) said.

He said the insight offers a pathway to developing new drugs for the condition.

If some researchers develop a magic pill that destroys the CPAP market, they should make tons of money.

chunkyfrog · Post by **chunkyfrog** » Wed Apr 17, 2024 11:07 am

" . . . The study might be useful to justify additional studies:"

I can also see how these results could be ported directly over to advertising--
As is so often done.
Forget definitive study--just do enough to fool the maggots.

New spray offers hope for people with common sleep condition

New spray offers hope for people with common sleep condition

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Re: New spray offers hope for people with common sleep condition

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Re: New spray offers hope for people with common sleep condition

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