RLS: Magnesium Type?

yourbrokenoven wrote: ↑

Mon Mar 19, 2018 6:14 am

I've been a nurse 12 years and had never heard of taking magnesium for restless leg syndrome.

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Our study indicates that magnesium treatment may be a useful alternative therapy in patients with mild or moderate RLS-or PLMS-related insomnia. Further investigations regarding the role of magnesium in the pathophysiology of RLS and placebo-controlled studies need to be performed.

https://www.ncbi.nlm.nih.gov/pubmed/9703590

Low levels of magnesium can cause neurons to become more easily excited, thus affecting a person’s mental status. As a result, magnesium supplements are often used to stabilize neuronal membranes and prevent abnormal activity in the nervous system (Trenkwalder 2008).

http://www.lifeextension.com/Protocols/ ... me/Page-05

Does anyone happen to know more about the PubMed article, like what kind of magnesium was used?

Wantok wrote: ↑

Sat Mar 24, 2018 6:36 pm

Does anyone happen to know more about the PubMed article, like what kind of magnesium was used?

Magnesium Oxide

The Study wrote:After polysomnography, patients were given 12,4 mmol magnesium (magnesiumoxide) in the evening over a period of 4-6 weeks (mean 5.1 weeks).

Here's the full paper: http://www.olivamine.com/sites/default/ ... nd-RLS.pdf

Jay Aitchsee wrote: ↑

Sun Mar 25, 2018 5:01 am

Wantok wrote: ↑

Sat Mar 24, 2018 6:36 pm

Does anyone happen to know more about the PubMed article, like what kind of magnesium was used?

Magnesium Oxide

Ugh, the least bioavailable magnesium form in existence....

mostly laxitive.

palerider wrote: ↑

Sun Mar 25, 2018 11:07 am

Jay Aitchsee wrote: ↑

Sun Mar 25, 2018 5:01 am

Wantok wrote: ↑

Sat Mar 24, 2018 6:36 pm

Does anyone happen to know more about the PubMed article, like what kind of magnesium was used?

Magnesium Oxide

Ugh, the least bioavailable magnesium form in existence....

mostly laxitive.

I know, right?
I didn't read the article closely, but I think at least one person had to drop out of the study due to diarrhea

Thank you so much, Jay, for the report! No one dropped out because of diarrhea, but no matter, I can't tolerate it. Does the mmol mean it was taken in a liquid form? Does anyone know what that might be in mg's?

I take magnesium bisglycinate and malate (and a malate concoction sold by the leg cramps mag sellers online as I was taking it mainly for nocturnal leg cramps). But I have been taking it throughout the day and I guess I might think of taking it all before bed?

12.4 mM of means 12.4 / 1000 moles, and moles is the gram molecular weight. Moles are a number of molecules, can be in a solution or not, only matters that its 12.4 mM, with since the MW of MgO is 40.304 g/m, thats a dose of 500 mg. Or one standard tablet.

Wantok wrote: ↑

Sun Mar 25, 2018 2:56 pm

Thank you so much, Jay, for the report! No one dropped out because of diarrhea, but no matter, I can't tolerate it. Does the mmol mean it was taken in a liquid form? Does anyone know what that might be in mg's?

I take magnesium bisglycinate and malate (and a malate concoction sold by the leg cramps mag sellers online as I was taking it mainly for nocturnal leg cramps). But I have been taking it throughout the day and I guess I might think of taking it all before bed?

I take magnesium bisglycinate as well, 200mg at noon and 200mg at bedtime. I'm not positive, but I seem to recall that in another study that saw positive results from magnesium supplementation, it was administered at bedtime. I believe that study used magnesium citrate, but I don't remember for sure. I know it wasn't magnesium oxide. What ever was used was becaused of the improved bioavailability over the oxide.

Wantok wrote: ↑

Sun Mar 25, 2018 2:56 pm

No one dropped out because of diarrhea, but no matter, I can't tolerate it.

Magnesium citrate is sold in liquid form for relief of constipation. The solution contains 1.75 g of magnesium citrate per liquid ounce. The dosage instructions say take 6.5 to 10.0 ounces and expect relief with one to four hours. So, the standard dosage has about 11 to 17 g of magnesium citrate. I would think as a supplement of 500 mg, magnesium citrate would not effect the bowel. But, some individuals may be sensitive to even this very low dose.

https://dailymed.nlm.nih.gov/dailymed/d ... 2efc1665d1

ChicagoGranny wrote: ↑

Mon Mar 26, 2018 7:33 am

Magnesium citrate is sold in liquid form for relief of constipation. The solution contains 1.75 g of magnesium citrate per liquid ounce. The dosage instructions say take 6.5 to 10.0 ounces and expect relief with one to four hours. So, the standard dosage has about 11 to 17 g of magnesium citrate. I would think as a supplement of 500 mg, magnesium citrate would not effect the bowel. But, some individuals may be sensitive to even this very low dose.

Magnesium citrate is a C6H6MgO2, the molecular weight is 214 g/mol. So if you would like to take 12.4 mmol => 2.6 g
Magnesium oxide is MgO, MG = 40 g/mol and 12.4 mmol as mentioned before = 0.5 g
The 11 to 17 g of magnesium citrate is 5 times more Mg than in the 0.5 g MgO. But the high Mg citrate is used as a saline laxative, relieve constipation, Not to be adsorbed by the body. Mg Citrate is 12% more soluble when compared to MgO and both salt however are rapidly eliminated in the urine.

Try natural products with high Magnesium:
Pumpkin seeds, peanuts, walnuts, banana.

I prefer dietary sources because nature tends to put different compounds together,
that might get stripped off during factory hijinks.

chunkyfrog wrote: ↑

Mon Mar 26, 2018 10:33 am

I prefer dietary sources because nature tends to put different compounds together,
that might get stripped off during factory hijinks.

you are so right... grow your own pumpkin, roast the seed with just a tiny bit of salt and enjoy with a glass of good red wine.

It is nearly impossible to get enough magnesium from food unless you count the "assumed" magnesium amount from your food every meal. This is why it is well know that most of the population is magnesium deficient and you do not want to be deficient in this very important mineral. To be effective, magnesium must be taken throughout the day, or even better, take sustained release magnesium supplements, half the dosage in the AM and the remaining in the PM. Magnesium in food, or instant release forms of supplements, are quickly absorbed and much of it is not used.

I do not watch Dr. Oz, but I did watch on his website several months ago a segment that he did explained how to get the correct dosage, and timing, of taking magnesium from food only. I knew by the title of the segment that is was going to be a laugh riot on how he expects people to do this. He explained the short life of magnesium and how it had to be eaten throughout the day. So, he recommended specific foods be eaten during each meal to meet the requirements. He actually thought that people were going to follow this food regiment every day to get the magnesium. Totally, not going to happen because it was so difficult. (Do you plan every meal keeping track of the magnesium on everyone's plate? Again, not going to happen.)

Above I mentioned "assumed magnesium amount" in foods. What makes you think that the magnesium amount in every food type matches what has been published? Farming methods have changed so much in the past many years that the mineral and vitamin contents in any food should always be suspect. It is highly likely that the mineral or vitamin content on the label, or in your preferred reference guide, is very variable to say the least.

Do yourself a favor, take a high quality, sustained release, supplement every day. You will feel better, sleep better with no nighttime leg cramps (that alone may taking the supplement a winner for me) and help your heart. Magnesium is the "great relaxer" and is recommended by many cardio doctors.

Dr Oz is a SALESMAN.
I could go into more detail, but he can afford better lawyers than I.

I agree, which is why I never watch his TV show. However, on his website you can pick any segment that looks interesting (at least it used to, but I have not checked it for a long time). In this case, magnesium, he was not selling anything, just explaining how important magnesium is and how to get it with food only. This is nearly impossible to do, but he tried his best to show how to do it. He was serious in his explanation, but it is just stupid to think anyone would be able to do it on a daily basis. You can not get enough magnesium with just food, well technically possible I guess, like flying to the North Pole next week is possible but no one is going to to do it every day.